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KMID : 0613820100200060922
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Journal of Life Science
2010 Volume.20 No. 6 p.922 ~ p.928
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Evaluation of In-vitro Anticoagulation Activity of 33 Different Medicinal Herbs
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Ryu Hee-Young
Kim Jong-Sik
Sohn Ho-Yong
An Seon-Mi
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Abstract
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This study was carried out to develop safe and novel anticoagulation agents from oriental medicinal herbs. From 33 medicinal herbs, 40 different ethanol extracts were prepared according to place of origin or extraction parts, and anticoagulation activities were evaluated by determination of thrombin time (TT), prothrombin time (PT) and activated partial thromboplastin time (aPTT). The average water content and average extraction ratio for the medicinal herbs were 6.85±2.26% and 5.27±4.25%, respectively. Evaluation of TT at various concentrations of the extract led to the selection of Mucuna birdwoodiana, Prunus armeniaca, Cacalia ainsliaeiflora, Cinnamonum aromaticum, and Rhus javanica Linneas potent antithrombosis medicinal herbs. Evaluation of PT and aPTT showed that the extracts of R.javanica Linne, M. birdwoodiana, and P. armeniaca have strong anticoagulation activities. Determination of hemolytic activities of 40 different ethanol extracts against human red blood cells, however, showed that only M. birdwoodiana, C. ainsliaeiflora, C. aromaticum, and R. javanica Linnehas strong anticoagulation activity without hemolytic activity at a concentration of 500 mg/ml. Our results suggest that oriental medicinal herbs, which are under a mass-production system, have potentialas a safe and novel source of anticoagulants, as well being a thrombin-specific and coagulation factor-specific inhibitor.
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KEYWORD
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Oriental herbal medicines, anticoagulation activity, activated partial thromboplastin time, prothrombin time, thrombin time, hemolytic activity
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